For Healthcare Professionals

Epidemiology

• Pheochromocytomas are diagnosed in 1 to 6 per million people per year
• It has an annual incidence in the United States of 500 to 1,100 cases per year
• Peak incidence occurs at age 30-50
• Pheochromocytomas occur in about 0.1%-0.5% of patients with hypertension
• Paragangliomas occur in approximately 15%-20% of individuals diagnosed with pheochromocytoma
• Prevalence of malignant pheochromocytomas has been commonly reported to be approximately 10%, although it may be as high as 33% or higher, depending on how malignancy is defined and the underlying genetic mutation