The most common sign of Pheochromocytoma and Paraganglioma is uncontrolled elevated hypertension.

Signs and symptoms may occur weekly, several times daily, or once every few months. Most attacks last less than an hour, but rarely more than several days.

Attacks may be induced by postural changes, anxiety, trauma, pain, use of medications (histamine, glucagon, tyramine, phenothiazine, metoclopramide, adrenocorticotropic hormone, pseudoephedrine), certain medical procedures (intubation, anesthesia, endoscopy, catheterization), treatment (chemotherapy), and urination or bladder distention (with bladder tumors).

Signs% of Patients
Hypertension 98
Sustained 50-60
Paroxysmal 50
Orthostatic Hypotension 12
Pallor 30-60
Flushing 18
Fever up to 66
Hyperglycemia 42
Vomiting 26-43
Convulsions 3-5
Headache 70-90
Palpitations +/- tachycardia 50-70
Diaphoresis 60-70
Signs% of Patients
Anxiety 20
Nervousness 35-40
Abdomincal / Chest Pain 20-50
Nausea 26-43
Fatigue 15-40
Dyspnea 11-19
Dizziness 3-11
Heat Intolerance 13-15
Pain / Parensthesias up to 11
Visual Symptoms 3-21
Constipation 10
Diarrhea 6
Signs% of Patients
Hypertension 98
Sustained 50-60
Paroxysmal 50
Orthostatic Hypotension 12
Pallor 30-60
Flushing 18
Fever up to 66
Hyperglycemia 42
Vomiting 26-43
Convulsions 3-5
Headache 70-90
Palpitations +/- tachycardia 50-70
Diaphoresis 60-70
Signs% of Patients
Anxiety 20
Nervousness 35-40
Abdomincal / Chest Pain 20-50
Nausea 26-43
Fatigue 15-40
Dyspnea 11-19
Dizziness 3-11
Heat Intolerance 13-15
Pain / Parensthesias up to 11
Visual Symptoms 3-21
Constipation 10
Diarrhea 6